Opening windows into
mitochondrial function

New research tools that probe the redox state of mitochondria in tissues

Cellular Energetics

Cellular function depends on a complex pathway of oxygen transfer from hemoglobin to myoglobin and into mitochondria, where oxygen is the terminal receiver of the electron in the mitochondrial electron transport chain allowing the continued production of energy in the form of ATP. Understanding the redox state of mitochondria is currently limited to in vitro models and indirect, post-hoc analyses. Direct, in-vivo monitoring of mitochondria in living tissues would open new directions of research and care.

CAUTION: Investigational device. Limited by Federal Law to investigational use only.

Oxygenation in a new light

Our microvascular oximeter research promises to bring new information about local oxygen delivery and consumption to the bedside

Microvascular Oximetry

Pendar Technologies has ongoing trials of microvascular oximeters to evaluate peripheral StO2 as a marker for reduced oxygen supply in systemic conditions such as hemorrhage, sepsis, and cardiac failure. By integrating a high resolution spectrometer, small flexible probes, and sophisticated algorithms into a compact form factor, it is possible to deliver highly accurate, continuous measurements while managing costs and usability in the critical care environment.

Portable spectroscopy of oxygen utilization in the peripheral microvasculature will give caregivers a better understanding of hemodynamics at the bedside. Moving beyond traditional tools such as pulse oximetry and invasive catheters, oximeters based on Resonance Raman Spectroscopy (RRS) and other modalities non-invasively capture data at the capillary level of peripheral tissues.

Hemoglobin Saturation

Pendar Technologies has ongoing research into oximeters able to assess oxygen saturation in-situ through existing bags or tubing. By integrating a high resolution spectrometer, small flexible probes, and sophisticated algorithms into a compact form factor, it is possible to deliver highly accurate, rapid measurements in environments such as blood banks.

Because RRS is based on sharp vibrational peaks, it is highly specific to target molecules and thus less sensitive to interfering substances. Real time measurements are possible through blood bags, for example, allowing research into the oxygen trends of stored blood.

CAUTION: Investigational device. Limited by Federal Law to investigational use only.