Oxygenation in a new light

Our microvascular oximeter research promises to bring new information about local oxygen delivery and consumption to the bedside

Microvascular Oximetry

Pendar Technologies has ongoing trials of microvascular oximeters to evaluate peripheral StO2 as a marker for reduced oxygen supply in systemic conditions such as hemorrhage, sepsis, and cardiac failure. By integrating a high resolution spectrometer, small flexible probes, and sophisticated algorithms into a compact form factor, it is possible to deliver highly accurate, continuous measurements while managing costs and usability in the critical care environment.

Portable spectroscopy of oxygen utilization in the peripheral microvasculature will give caregivers a better understanding of hemodynamics at the bedside. Moving beyond traditional tools such as pulse oximetry and invasive catheters, oximeters based on Resonance Raman Spectroscopy (RRS) and other modalities non-invasively capture data at the capillary level of peripheral tissues.

CAUTION: Investigational device. Limited by Federal Law to investigational use only.

Opening windows into
the beating heart

New tools that probe the redox state of mitochondria in living tissue

Cellular Energetics

Cellular function depends on a complex pathway of oxygen transfer from hemoglobin to the myoglobin and into the mitochondria, where oxygen is the terminal receiver of the electron in the mitochondrial electron transport chain allowing the continued production of energy in the form of ATP. Understanding the redox state of the mitochondria is currently limited to in vitro models and indirect, post-hoc analyses. Direct, in-vivo monitoring of mitochondria in living tissues would open new directions of research and care.

Working with researchers at Boston Children’s Hospital, Pendar Technologies has developed a system for real-time quantification of hemoglobin oxygen saturation, myoglobin oxygen saturation, and mitochondrial redox state. Taking peri-operative measurements from a beating, perfused heart, our Resonance Raman Spectroscopy based tool is enabling new research into the causes of sudden cardiac arrest in patients recovering from cardiac surgery with the aim bringing the technology to the clinical market.

CAUTION: Investigational device. Limited by Federal Law to investigational use only.